Published · Aurelis Peptides
MOTS-C and Humanin are different peptides within the mitochondrial-derived peptide research field. The MOTS-C discovery paper describes a 16-residue peptide. The Humanin form discussed here has 24 residues. Their shared research category does not make the names interchangeable.
Aurelis lists MOTS-C 40 mg per unit. Humanin is a literature comparator on this page; it is not an additional catalogue entry. This guide connects the names with their original research, then explains what the existing MOTS-C listing actually specifies.
MOTS-C vs Humanin at a glance
A residue is an amino-acid building block within a peptide. Both the number and order of those building blocks help identify the molecule. Start with the full name before comparing a headline or an amount.
| Comparison field | MOTS-C | Humanin |
|---|---|---|
| Name used in papers | MOTS-c; styled MOTS-C in this catalogue | Humanin; often abbreviated HN |
| Peptide length discussed here | 16 residues in the 2015 discovery report | 24-residue form in the cited Humanin work |
| Genetic-region context | Short reading frame within mitochondrial 12S rRNA | Humanin coding sequence associated with the mitochondrial 16S rRNA region |
| Research examples below | Metabolic regulation and stress-responsive gene activity | Neuronal-cell survival and interactions with a cell-death protein |
| Aurelis listing | 40 mg listed content per unit | Literature comparison only |
The identity and genetic-region fields follow the 2015 MOTS-c discovery report, 2001 Humanin report and 2002 Humanin production study. The table compares defined materials and research questions; it does not rank their effects.
What is Humanin?
Hashimoto and colleagues identified Humanin through a functional screen using a brain-derived cDNA library. In their 2001 study, they investigated neuronal cells exposed to particular Alzheimer-related genetic and amyloid stressors. The reported cell-survival response depended on Humanin's structure and did not extend to every experimental cause of cell death they tested. Read the original study abstract.
A 2002 follow-up examined whether Humanin could be produced in biological systems. The authors reported that a cDNA containing its coding region closely matched the mitochondrial 16S rRNA sequence, and they investigated peptide production and antibody detection. This helps explain the genetic-origin question behind the name. Read the Humanin production abstract.
These are specific experimental observations. Keep the named peptide, tested cell system and measured outcome together when reading a Humanin reference. A neuronal-cell result does not describe the composition or performance of a MOTS-C product.
What is MOTS-C?
Lee and colleagues described MOTS-c in 2015 after identifying a short reading frame in the mitochondrial 12S rRNA region. Their work examined metabolic regulation in cell experiments and mouse models, including insulin-response measurements. It established a separate research identity from Humanin. Read the MOTS-c discovery paper.
The capitalisation MOTS-c or MOTS-C is a writing convention in these references and catalogue pages. It is not enough to distinguish a new chemical form. For a material enquiry, retain the complete molecular specification rather than relying on a spelling variant.
How do the research questions differ?
A 2018 MOTS-c study investigated communication between mitochondria and the cell nucleus. In cultured cell experiments, metabolic stress was associated with movement of MOTS-c into the nucleus. The researchers examined AMPK-dependent movement and changes in stress-responsive gene activity. AMPK is an enzyme involved in cellular energy sensing. Read Kim and colleagues, 2018.
For Humanin, a 2003 study examined Bax, a protein involved in a cell-death pathway. The authors reported Humanin-Bax interactions and changes in Bax movement to mitochondrial membranes. Their experiments also examined isolated mitochondria and cytochrome-c release. That is a different molecular question from the MOTS-c nuclear-signalling study. Read Guo and colleagues, 2003.
The cited experiments were not a direct MOTS-C-versus-Humanin contest. Compare their outcomes by stating what each measured: a protein interaction, gene activity, cell survival or a metabolic response. Shared mitochondrial language alone does not establish equal activity or a combined effect.
Does “mitochondrial-derived” describe the supplied material?
In these papers, the term connects the peptides with genetic-origin and signalling research. It does not identify how a particular commercial material was manufactured, what chemical form it contains or whether its batch matches a paper's preparation.
Keep those questions separate in a reading note. Record the peptide name and study reference first. Then record the offered material's sequence or identity specification, chemical form and batch identifier. The quality-documentation guide explains the distinct roles of identity, purity and measured content.
What does MOTS-C 40 mg mean?
The Aurelis MOTS-C 40 mg listing states content per unit. It does not state concentration, liquid volume or an amount delivered by a device. A matching mg number on another peptide would not establish the same molecule or the same biological activity.
Use the content versus concentration guide to read those quantity fields. For a separate comparison with a mitochondrial membrane-targeting peptide, see MOTS-C vs SS-31. Humanin and SS-31 are different comparators, so the two pages answer separate naming and research questions.
Build a focused MOTS-C enquiry
State MOTS-C 40 mg, the quantity required and your destination. Identify the preferred presentation explicitly. Aurelis shows both vials and pen-style kits; confirm the actual configuration available for the selected entry. A format image does not fill in its final formulation or device specification.
If you are comparing a paper with an offered material, include the reference and ask for the matching identity and content records. A blend enquiry needs a complete component specification of its own; this family comparison does not create a Humanin and MOTS-C blend. See the blend specification guide for those additional fields.
Aurelis has warehouses in Australia, Canada and the USA. Confirm current local availability and dispatch for the selected order. Send a MOTS-C enquiry or email sales@aurelispeptides.com.
Primary sources
- Lee et al., Cell Metabolism, 2015 — MOTS-c discovery and metabolic experiments.
- Hashimoto et al., PNAS, 2001 — original Humanin neuronal-cell study.
- Tajima et al., Neuroscience Letters, 2002 — Humanin coding-region and peptide-production research.
- Kim et al., Cell Metabolism, 2018 — MOTS-c nuclear localisation and stress-responsive gene activity.
- Guo et al., Nature, 2003 — Humanin and Bax experiments.